Can I use the USA version in the UK?

Hi guys. I think I have my heart set on the 6P (over the 5X). I can get my hands on one from the States but I live in the UK. Will I have any usability issues at all? I did see a thread that listed the connectivity channels and the USA version has less channels on LTE and UMTS than the rest of the world version; will this affect me using it in the UK?

Is there anything else I should be aware of when getting a phone from the USA but living in and using it only in the UK?

Thanks.